Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality.

نویسندگان

  • L Mazat
  • S Lafont
  • C Berr
  • B Debuire
  • J F Tessier
  • J F Dartigues
  • E E Baulieu
چکیده

The decrease with age of the adrenal-secreted dehydroepiandrosterone sulfate (DHEAS) in serum has suggested that it may be causally related to longevity. For the PAQUID [People (Personnes) Aged (Agées) About What (Quid, in Latin)] cohort of elderly subjects, we have previously reported higher DHEAS in men than in women, a decrease with age and, among men, a negative correlation between the DHEAS level and mortality at 2 and 4 years. Here, with an 8-year followup in 290 subjects, we show a global decrease of 2.3% per year for men and 3.9% per year for women. However, in approximately 30% of cases, there was an increase of DHEAS. We observed no relationship between the evolution of DHEAS level and functional, psychological, and mental status, possibly because of selection by death. In women, no association was found between mortality and DHEAS level. In men, the relative risk (RR) of death was higher for the lowest levels of DHEAS (RR = 1.9, P = 0.007), with RR = 6.5, P = 0.003 for those under 70 years old, a result indicating heterogeneity of the population. There was an effect of subjective health on mortality that disappeared after adjustment of DHEAS levels, suggesting its relation with these DHEAS levels. Death RR was much higher in smokers with a low DHEAS level than in nonsmokers with high DHEAS (RR = 6.7, P = 0.001). We submit that the involvement of DHEAS is possibly different according to gender, that association between low DHEAS level and mortality only for men under 70 years old possibly reflects heterogeneity of the population, and that DHEAS level is a reliable predictor of death in male smokers.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Associated factors of headache in a cohort of elderly subjects

Background: Headache and depression are prevalent among general population. The aim of this study was to determine the associated factors of headache in elderly subjects with emphasis to depression. Methods: All cohort of elderly individuals of the Amirkola Health Study Project were included. Data regarding several clinical and demographic characteristics were provided via fill in quesstionn...

متن کامل

Relationship between Tooth Loss and Physical Activity, Dietary Habits and Smoking in Residents of Yazd City (YaHS Study)

Introduction: Tooth loss is debilitating and affects the quality of life. This problem has multiple etiologies like microorganisms, physical activity, nutrition and smoking. The aim of this study was to determine the relationship between tooth loss and physical activity, dietary habits and smoking in adults of Yazd City. Methods: This descriptive cross sectional study was conducted using the i...

متن کامل

به کارگیری فراتحلیل بیزی برای برآورد خطر نسبی مرگ در بیماران کرونری قلبی بعد از ترک سیگار

Background and objective: Numerous studies have reported beneficial effects of smoking cessation in terms of decreased cardiovascular mortality in patients with coronary heart disease. This paper aimed to determine a valid estimate for the relative risk of mortality in subjects who quit smoking compared to those continued smoking. Methods: All relevant prospective cohort studies of chronic hear...

متن کامل

Association between Lifestyle Satisfaction and Tendency to Behavioral Change with Health Related Quality of Life among 40 Years Old and Over in (North of Iran) Mazandaran

Background and purpose: Health related quality of life (HQOL) has different dimensions and many factors affect it. The aim of this study was to investigate the association between lifestyle satisfaction and health- related quality of life in the population aged 40 year old and over. The question is, if there is not lifestyle satisfaction, how should be the pattern of tendency to behavioral chan...

متن کامل

Non-leisure time physical activity is an independent predictor of longevity for a Taiwanese elderly population: an eight-year follow-up study

BACKGROUND The aim of this study is to determine the relationship between leisure time physical activity (LTPA) and non-leisure time physical activity (NLTPA) on mortality among the elderly in Taiwan. METHODS This is a prospective observational cohort study. We analyzed the mortality data from a cohort of 876 non-institutionalized community-dwelling men and women aged 65 years or over, who we...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 98 14  شماره 

صفحات  -

تاریخ انتشار 2001